Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO.
نویسندگان
چکیده
In a remarkably conserved insulin signaling pathway that is well-known for its regulation of longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF-16/FOXO, also modulates many other physiological processes. This raises the question of how DAF-16/FOXO chooses the correct targets to achieve the appropriate response in a particular context. Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output.
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عنوان ژورنال:
- Developmental dynamics : an official publication of the American Association of Anatomists
دوره 239 5 شماره
صفحات -
تاریخ انتشار 2010